On was cytotoxic but did not enhance or abrogate the cytotoxic effects of imatinib in GIST-T1 cells. Thus, IGFBP3 has cell-dependent effects on GIST cell viability and in mediating imatinib response.ResultsHeterogeneous induction of IGFBP3 after imatinib in GIST cell lines To study the role of IGFBP3 in GIST, we used two available GIST cell lines: GIST882 and GIST-T1. The GIST882 cell line harbors
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