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The WT mice, 12 of the 13 being significant increases (Tables 3 and 4). By contrast, there were only 4 significant changes between 4 and 24 hr in the SPA-/- mice. However, in general the response patterns were quite similar in both strains with 41 proteins (excluding SP-A) showing either increases or decreases in both strains (Table 3) and 18 more that showed increases in one strain and decreases

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