Ting of the Roc1a NH2 terminus fused to the RING domain of the more distantly related Roc2 (AN2R) was unable to bind any Cullin. Substituting in the Roc1b RING domain, however, was able to restore Cullin binding, and the resulting ANBR protein displayed a Cullin binding profile identical to Roc1a. This suggests that a region of the RINGBinding Determinants of Rocsexplained if Roc1b interacts with
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